Pharmaceutical

From drug discovery through development, into manufacturing and QA/QC, HPLC is vital. Whether it be ultrafast, high-resolving screening or reliable quality control, Dionex UHPLC+ offers a highly scalable platform for the  pharmaceutical value chain. With the benefit of built-in simplicity, the Chromeleon^® chromatography data system  is a widely prescribed standard providing maximum confidence in results through 21 CFR Part 11 and GxP compliance tools.

Drug Discovery

The UltiMate^® 3000 RSLCnano and RSLC systems are typically used in drug discovery labs. The RSLCnano is designed predominantly for the analysis of large molecules in drug discovery labs, and the RSLC is better suited to small molecule analysis.

Analysis of a peptide digest with the RSLCnano system. The peak capacity is 750, obtained using a 50 cm column, with 75 µm internal diameter and 2 µm particles.

Method Development

The UltiMate 3000 RSLC is ideal for method development. It features a column compartment that can hold up to 12 columns, and integrated switching valves that allow for automated method scouting. Advanced method development tools are available through our tie-in with ChromSword (® of IRIS Technologies International, Ltd.).

QA/QC

Dionex has many solutions that support QA/QC workflows. These include

• UltiMate 3000 Standard system. Fully UHPLC compatible and designed for routine, high up-time operation
• Corona^® Charged Aerosol Detector – this universal detector is ideal for analyses such as cleaning validation, and impurity profiling
• Chromeleon Extension Pack – offers tools for ICH method validation, impurity testing, content uniformity, and dissolution testing

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